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The accumulation of M1 macrophages triggers activation of JNK and IKK pathways through pattern-recognition receptor engagement, promoting insulin resistance through stress kinase signaling mechanisms (69, 70)

Proc Natl Acad Sci USA 118(52)

(2024) showed that CBD treatment reversed chemotherapeutic stress-induced depressive behaviors and noted that CBD inhibits iNOS expression via PPAR (Poudel et al

10.3389/fphar.2022.916732 4 AndreuxP

34 The dynamic shuttling of lactate between the muscles and liver, facilitated by vascular connections, underscores its crucial role in metabolic homeostasis