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Interestingly, the DNA damage repair protein RRM2, often upregulated in NB to support oncogenicity, was upregulated across all conditions, and phosphorylation at the Ser-80 and Ser-86 sites was significantly downregulated by both combinations ( Supplementary Table S1 ) (4749)

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Regulatory decisions regarding GLP-1 agonists reflect the ongoing dialogue between pharmaceutical companies, regulatory agencies, and the medical community to ensure the availability of safe and effective treatment options for patients in need