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doi: 10.1016/j.freeradbiomed.2005.02.026

furthermore, MK2206-treatment revealed increased mean fluorescent lifetime (tm) of NADPH and NADH species without and with IR, particularly in the untreated TrC1 AKT-E17K cells, hinting to an increase of NADH levels as a potential cause for the decreased NADPH/NADH ratio ( Figures S3G-I )

To further confirm this observation, we carried out MD simulations

Practical Considerations: Convenience, Cost, and Accessibility Injections are stronger, but they take more time and usually cost more

10.1016/j.actbio.2022.04.024 Summary Keywords multiple myeloma, ferroptosis, pharmacological mechanism, natural products, antitumor effects Citation Shi J, Lu Y, Wei W, Ma G, Li C, Li L, Wang Y, Wang Y, Xu R and Cui S (2025) Ferroptosis: a novel pharmacological mechanism against multiple myeloma