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Unlike flavones, flavanones lack the double bond between C-2 and C-3, resulting in a saturated C ring (Cook and Samman 1996)

IGFBP-5, also reported to be concerned in neuron survival processes, was increased mainly in the hypothalamus, suggesting a attainable neuroendocrine role

Patients reported better sleep and overall recovery

This protein forms aggregates that disrupt cellular processes, causing progressive motor dysfunction, cognitive decline, and psychiatric symptoms

Except in cases where interactions with specific flavonoids are clearly defined, it seems prudent to avoid treatment with flavonoids in therapeutic doses concurrently with tamoxifen

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