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Figure 4 Furthermore, inhibition of GS by BSO significantly increased ROS levels 24 h after treatment in TrC1 AKT-WT and AKT-E17K cell lines ( Figures 4D, E ) and enhanced cell death in AKT-WT and Akt-E17K mutant cell lines irrespective of additional irradiation with a dose of 5 Gy after 48 h ( Figures 4F, G )

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Multi-peptide formulations offer a way to study how different remodelling signals interact and whether combinatorial approaches produce effects distinct from single-peptide treatments