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Copper may influence the expression of A degrading enzymes such as neprilysin (NEP) and insulin-degrading enzyme (IDE), leading to insufficient A clearance, which in turn affects decision-making, planning, and executive functions (76)

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[207] found significantly reduced bone length in IGF2-null mice at postnatal periods prior to weaning (13 weeks of age) and their histological analysis suggests that IGF-2 may have a role in controlling the progression of chondrocytes from proliferation to hypertrophy

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[DOI] [PubMed] [Google Scholar] 108.Mandel S., Amit T., Reznichenko L., Weinreb O., Youdim M.B