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10.1016/j.stemcr.2020.04.011 Stem Cell Rep

AATD-associated liver disease (AATD-LD) is primarily caused by SERPINA1 protease inhibitor (Pi)*Z variants, of which the homozygous variant Pi*ZZ carries the greatest risk

Currently, ruxolitinib, tofacitinib, and baricitinib are among the drugs considered for AA treatment, with only tofacitinib and ruxolitinib having received FDA approval [16]

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Therefore, due both to a general lack of adequate research so far, as well as methodological limitations when it comes to ruling out possible placebo effects, all of the purported uses described below are currently considered to have insufficient evidence to come to any firm conclusions about the efficacy of neurofeedback training

This distinction might sound subtle, but it creates significant practical differences in how each supplement works and who benefits most from taking them