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Research overwhelmingly describes the safety of GHK-Cu positively, such as when the authors of a 2018 review called it a safe, inexpensive, extensively studied compound.14 However, even though copper peptides have demonstrated an impressive safety track record in studies, there are (as with most skin care actives) a few safety risks to consider

Case reports combining Epithalon with other therapeutic modalities show promising results for cognitive improvement

The safety margin sits approximately 300-fold above therapeutic doses, making GHK-Cu one of the most well-tolerated peptides available for research purposes

Conditions like Wilson's disease, a genetic disorder where the body cannot properly excrete excess copper, are an absolute contraindication

Decrease in skin inflammation and redness GHK-Cu has anti-inflammatory effects and can reduce redness, irritation, and swelling