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Volkova NV, Meier B, Gonzlez-Huici V et al (2020) Mutational signatures are jointly shaped by DNA damage and repair

Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes

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Better Retention Compared to Other Forms Some studies suggest the methylated form of B12 may have longer tissue retention than non-methylated forms, supporting ongoing B12 status

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