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Despite the extensive accumulation of evidence and proposal of multiple pathogenic mechanisms, there is much to learn about how these disorders develop and progress

The subcellular localization of iron within cancer cells may contribute to the diverse and sometimes conflicting effects of iron modulation

Gut microbiota promote angiotensin II-induced arterial hypertension and vascular dysfunction

Bacterial products such as LPS, predominantly derived by gramnegative organisms, can activate microglia TLR4 [214, 215], enhancing syn uptake, oxidative stress, and cytokine productionall contributing to neurotoxicity [216, 217, 218]

Close environment and asthma pathogenesis Recent researchers have proposed that environmental exposures can significantly influence the phenotype of allergic diseases, including asthma (57)