vitamin b12 1000mcg ml injection Cyanocobalamin 1,000 mcg / 1 mL 12 solution to be administered through injection only Intended for use in cats Cyanocobalamin 1,000 mcg / mL

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Direct impact can shear peptide bonds through mechanical force, damaging the compound before it even dissolves

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Key pathophysiologic mechanisms include: Mucosal barrier dysfunction: Impaired epithelial tight junctions allow bacterial translocation, triggering innate immune activation T-helper cell dysregulation: Predominantly Th1 and Th17 pathways drive chronic inflammation via TNF-, IL-12, IL-23 the basis for biologic therapy targets Transmural inflammation: Unlike UC (mucosal only), CD involves all layers: mucosa submucosa muscularis propria serosa Granuloma formation: Non-caseating granulomas are pathognomonic but present in only ~3050% of biopsies Fibrosis and stricture: Chronic inflammation activates myofibroblasts collagen deposition luminal narrowing obstructive symptoms Fistula formation: Transmural ulcers penetrate serosa form sinus tracts connect to adjacent bowel, bladder, vagina, or skin 7

Journal of Clinical Endocrinology & Metabolism, 95(7 Suppl 1), S1-S66