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The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor beta signaling

Yet B12 deficiency is remarkably common, affecting vegetarians, vegans, older adults, and anyone taking certain long-term medications like metformin or proton pump inhibitors

While promising, these findings need to be replicated in well-designed human trials to confirm its effectiveness and safety in people

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