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Key signaling pathways involved in reversing chemotherapy resistance include the GPX4-regulated pathway, oxidant and antioxidant system, iron metabolism, and lipid metabolism, all of which offer novel approaches to enhance chemotherapy efficacy [Figure 2]

Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders

In addition, RSV can suppress the occurrence of ferroptosis in the myocardium by increasing SLC7A11/GSH and GPX4 [193, 195]

Byrne ST, Denkin SM, Zhang Y

High-fructose corn syrup enhances intestinal tumor growth in mice