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Development of antagonists that target FcRn, so as to increase IgG catabolism, thus represents a universal, yet targeted approach for the treatment of IgG-mediated autoimmune diseases [22]

Neuroprotection Against Parkinsons Models MPTP selectively destroys nigrostriatal dopaminergic neurons, producing tremor, rigidity, akinesia, and catalepsy in rodents

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BMC Cardiovasc Disord 18(1):23

Additionally, terminal complement pathway activation generates membrane attack complexes (MAC), which build pores in the MM cell membrane, resulting in direct cell lysis [61, 62]