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[Abstract]2021 Oct;24(4):729

N Engl J Med 343(20):14671476 Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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Plasma HCV RNA declined rapidly from baseline by 3.4 log10 IU/mL in HCV-3 patients, and mean viral load reductions were similar in 50- and 100-mg dose groups with more sustained virological suppression after cessation of dosing in the 100-mg group.[82] On the other hand, GS-5816, a second-generation NS5A inhibitor, with anti-viral activity against all HCV genotypes, is well tolerated and has demonstrated potent anti-viral activity against HCV genotypes 1-4.[83] NS5B polymerase inhibitors NS5B is an HCV RNA-dependent RNA polymerase that plays a crucial role in HCV replication

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