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(Investigator) 9/04/26 9/06/27 Project: Research Anderson, I

Trihydroxycinnamic acid derivatives (esculetin, methylesculetin, daphnetin, and the glucosides, esculin and daphnin)

Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article

In those with MTHFR gene variants, folate and folic acid metabolism is inhibited in such that the vitamin is not efficiently reduced to its active form, 5-methyl-tetrahydrofolate (5-MTHF)