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For the non-randomized/observational studies, the methodological quality was assessed using Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I)

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Pharmacol Res 32:383389 Virmani MA, Caso V, Spadoni A, Rossi S, Russo F, Gaetani F (2001) The action of acetyl-l-carnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurones

For individuals living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and postural orthostatic tachycardia syndrome (POTS), this cellular energy deficit is often experienced as a profound metabolic inflexibility