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Reactive electrophilic species (RES) have electron-deficient centers and can react with the nucleophilic Cys thiol group via the thiol- S -alkylation chemistry (Figure 2) (Antelmann and Helmann, 2011)

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Subsequent research must further clarify the role of the MGBA axis across varying malignancies, radiation site, and dose parameters (Li et al., 2022)

Mitochondrial dynamics: fission-fusion balance and structural function In terms of mitochondrial dynamics regulation, NTFs maintain mitochondrial network integrity by balancing fission/fusion proteins, with relevant mechanisms primarily supported by in vitro experiments and acute animal model evidence, and the strength of causal relationships still needing reinforcement