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The tobacco industry repeatedly cited Huepers opinion that cigarette smoking was not a significant contributor to the development of cancer

As the effects of nicotine are felt quickly and dissipate rapidly, those with a physical dependence will often need high amounts of the substance to feel its effects

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*Correspondence: Zhongbang Song, [email protected] These authors have contributed equally to this work This article was submitted to Plant Biotechnology, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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