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Mechanistically, metformin may activate Nrf2 through multiple pathways, including AMPK activation, inhibition of GSK-3mediated Nrf2 degradation, and modulation of intracellular redox homeostasis, all of which facilitate Nrf2 nuclear translocation and subsequent induction of downstream antioxidant genes 48,49

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A slightly lower concentration of 8-oxo-dg was found in the A-GSH group.[15] SOD-1: Superoxide is one of the main reactive oxygen species in the cell, and, as such, SOD serves a key antioxidant role

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The results can be life-changing, as highlighted in Carson Dalys Intracept story