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In a high-fat diet model of metabolic inflammation, garlic-derived EVs carrying miR-396e were found to drive macrophages from a pro-inflammatory M1 state toward an anti-inflammatory M2 phenotype, dampening adipose tissue inflammation associated with cardiovascular risk [261]

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The TME is hypoxic, and both hypoxia and high lactate concentrations may be key drivers of the recruitment and polarization of tumor-associated macrophages (TAMs) 147

Induced pancreatic cell proliferation and beta cell neogenesis were also seen in the rats that received treatment

This acetyl shield effectively hides the vulnerable peptide bonds from the destructive digestive enzymes in the gut, allowing the entire molecule to survive the gastrointestinal tract and pass seamlessly through the intestinal wall into the bloodstream

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