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Starting too high leads to severe GI side effects

Int J Mol Sci 14:1980519830 Singh V, Oliashirazi A, Tan T, Fayyad A, Shahi A (2019) Clinical and pathophysiologic significance of MRI identified bone marrow lesions associated with knee osteoarthritis

A high dosage of B12 is around 500-1,000 mcg a day, either given via oral supplements or B12 injections

Oral iron supplementation with Feralgine in inflammatory bowel disease: A retrospective observational study

Conservative dosing also reduces risk of excessive energy deficit and the metabolic stress markers (low T3, menstrual irregularity) that emerge when both compounds are pushed to upper dose ranges simultaneously.