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Despite low CNS penetration, some studies report detectable levels in the brain, supporting its potential for systemic biological effects without significant accumulation (Jzwiak et al

In the image the tree is seen to be receiving a water transfusion, in the same way a human who has lost too much blood would receive a blood transfusion

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Targeting VEGF/VEGFR to enhance effector T-cell function by antiangiogenic agents: VEGF is a crucial link between tumor growth and the immune response directed at that tumor since it promotes both neoangiogenesis and immunosuppression [78]