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They recognize antigens presented on MHC class I and exert effector functions by releasing cytolytic molecules like perforin and granzymes, directly killing antigen-presenting cells or vascular wall cells, and by producing pro-inflammatory cytokines such as IFN-, thereby exacerbating local tissue damage and inflammation ( In conclusion, elucidating the functions, specific biomarkers, and metabolic regulation of T cell subsets offers new theoretical foundations for immune-based interventions in atherosclerosis, highlighting targets such as specific cytokine pathways, surface receptors, transcription factors, and metabolic enzymes

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