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This exposes participants to cotinine (the main metabolite of nicotine found in the bloodstream) levels suggestive of moderate tobacco exposure, equivalent to that found in light/moderate cigarette smokers, the study notes

It is for this reason that smoking cessation tools - methods for quitting smoking - are used, and these can be products that replace the nicotine you would normally get from cigarette smoking (known as Nicotine Replacement Therapy or NRT), to nature based interventions that have shown promising effects on personal well-being

Similarly, a European population-based study showed a significant decrease in protamine 2 (P2) concentrations in smokers, which subsequently caused an abnormal elevation of the P1:P2 protein ratio [158]

Wehrli, PhD, at the University of Pennsylvania Perelman School of Medicine in Philadelphia

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