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Statistical analysis All data were expressed as mean standard error, and significance was estimated by using one-way analysis of variance (ANOVA) tests, followed by the Tukey test

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Deaths from SUD are increasing, rising from approximately 284,000 deaths in 2007 to 352,000 in 2017, creating a global health threat (6)

DOI:10.5772/65715

3.4 Endogenous TME-responsive release and activation Endogenous TME-responsive systems exploit biochemical gradients or pathological cues within tumor tissue to guide therapy-focused release or activation