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doi: 10.1128/spectrum.04370-22 68 IshikawaH.MatsumotoS.OhashiY.ImaokaA.SetoyamaH.UmesakiY.et al

Endocrine and metabolic causes: Thyroid disease, uncontrolled diabetes, polycystic ovary syndrome (PCOS), and luteal phase defects affect hormone balance needed to sustain pregnancy

It inhibits the activation of the transcription factor NF-B, reducing the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO)