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Supplementary material The Supplementary Material for this article can be found online at: References 1 DongEDuHGardnerL

MOTS-c is a short peptide (16 amino acids), which makes it relatively resistant to the enzymatic degradation that degrades larger peptides, but also means that reconstitution technique and storage conditions matter considerably

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These mechanisms raise a theoretical concern: could supratherapeutic doses accelerate unwanted vascular growth or disrupt dopamine signaling enough to produce neuropsychiatric symptoms

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