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8,449,916, the contents of which is herein incorporated by reference in its entirety

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1 Vannelli BG, Barni T, Orlando C, Natali A, Serio M, Balboni GC: Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: an immunohistochemical study

Briefly, an inverse correlation between IGF-1 (IGF-1/IGFBP-3 ratio) circulating levels and several markers for obesity, MetS, T2D, and CVD has been found

Protein kinase C inhibition protects bloodbrain barrier from sepsis-induced vascular damage