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The goal of HRT is to restore hormone balance and reduce symptoms, including insomnia

These pharmacokinetic characteristics reflect ACs poor gastrointestinal absorption, high first-pass metabolism, and possible efflux by transporters such as P-gp, which together significantly limit its oral bioavailability and therapeutic translation

doi:10.3109/03602532.2011.558093

The association between night shift work and breast cancer risk in the Finnish twins cohort

(2007) Clin Pract Epidemiol Ment Health, 3: 29