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Similarly, the PCI3405 significantly decreases PARP1, caspase-3 cleavage, and Bax/Bcl-2 ratio to reduce apoptosis and increase cell viability

In: Bajaj JS (ed) Diabetes

Additionally, it has also been suggested that altering the epigenetic landscapes by DNA methylation (histone/non-histone changes) aids in the maintenance and survival of CSCs which have been shown to exhibit resistance features at the individual level [76]