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CHAOS trial demonstrated that -tocopherol is able to reduce the incidence of myocardial infarction, however, failed to reduce the mortality in cardiovascular diseases (Stephens et al

doi: 10.1111/1756-185X.13802

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In this state of chronic neuro-inflammation, the enteric nervous system is essentially starved of the cholinergic and serotonergic signals it needs to function