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10.1016/B978-0-12-397156-2.00199-X 21 BasriA

Oct 2014;26(77):251-6

Research scenario Better conceptual fit Reason Testing GLP-1 plus satiety-pathway extension CagriSema Combines semaglutide with amylin analog activity Testing maximum receptor breadth Retatrutide Activates GIP, GLP-1, and glucagon receptors Studying diabetes plus obesity together Both Both have programs relevant to T2D and weight Comparing incremental vs radical next-gen strategy Both CagriSema extends GLP-1

This is understandable, as the field continues to prioritize data from double-blind, placebo-controlled, randomized, controlled trials (RCTs) as the benchmark for therapeutic adoption