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These effects were mediated through the activation of HIF-1-BNIP3/NIX-driven mitophagy, with ROS playing a critical role in initiating this process in Tibetan adaptation to hypoxia

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The co-administration of NAC, Coenzyme Q10 and the SOD mimetic MnTBAP enhances the expression of mitochondrial complex I subunits, and reduces ROS production, oxidized/reduced GSH ratio, mitochondrial dysfunction and cell death induced by D-galactosamine in the cultured hepatocytes isolated from liver resections [42]

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