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10.1128/AEM.03121-20 44

doi:10.1016/j.jemermed.2020.07.038 Ferri FF

GSTZ1, glutathione S-transferase zeta 1

Importantly, cilium assembly is enhanced at this stage, driven by the synergistic effect of E2 signaling activation and NOTCH signaling suppression, culminating in the upregulation of forkhead box J1 ( FOXJ1 ), a key transcription factor (TF) essential for ciliogenesis [19]

The majority (7075%) of non-functioning PitNETs are gonadotroph tumours as they are immunopositive in 60% of the cases (hormone negativity in 40% of cases) for FSH and LH but do not secrete them in significant quantities [3, 6]