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In particular, proteasome inhibitors bortezomib, carfilzomib, and ixazomib were approved by the US Food and Drug Administration (FDA) for treatment of multiple myeloma in 2003, 2012, and 2015, respectively (Manasanch and Orlowski, 2017)

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In the trial-product estimand, 19.3% of participants achieved a reduction of at least 30% in body weight

In comparison, in females taking a placebo, 9.2% had serious side effects

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