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doi: 10.1016/j.chest.2020.07.023 48 CuadradoA.PajaresM.BenitoC.Jimnez-VillegasJ.EscollM.Fernndez-Ginset al

Outcome Measures Primary Outcome Measures The primary outcome for PROTECT is confirmed symptomatic COVID-19 infection during treatment defined as the presence of both PCR confirmed SARS-CoV2 and one or more symptoms in keeping with COVID-19, including Respiratory, Constitutional and GI symptoms

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This points to the complexity of this regulation implicates that PARP enzymes function via both NAD + consumption dependent and independent pathways

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