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In: Stoker TB, Greenland JC, editors

Lpez de Castro, J

The DNA lesions, in turn, trigger a series of signal-transduction pathways, leading to cell-cycle arrest, DNA repair and apoptosis

10.1016/j.freeradbiomed.2018.06.037 49

This mechanism allows cancer cells to resist cell death and contributes to the development of resistance to docetaxel, a common chemotherapy drug used in advanced prostate cancer treatment (Zhao et al., 2024)