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The combination of surgical and pharmacological interventions represents a newer approach to managing complex obesity, and understanding the interplay between these treatments is essential for patient safety and optimal outcomes

178 For example, a cross-sectional study published in 2023 found that, compared with non-users of hormone replacement therapy, initiation of hormone replacement therapy five or more years after menopause was associated with increased tau protein accumulation apparent on brain PET scans, whereas initiation within five years of menopause was not

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