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Moreover, several GLUT inhibitors are under active development and demonstrate potent anticancer activity in preclinical models, although none have yet progressed to clinical evaluation [344, 346,347,348,349]

Given its role in hypertension, ACE is a prime target for drug therapy, with over one-sixth of blood pressure-lowering medications like captopril and temocapril, being ACE inhibitors [127, 128]

Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues

Dynamics of human mitochondrial complex I assembly: implications for neurodegenerative diseases

The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

Instead, their redox states vary across disease subtypes, differentiation stages, and even within tumor hierarchies, particularly between the bulk population and the relapse-driving stem cell compartment [119]