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However, therapies targeting these molecules have shown contradictory results, underscoring the need for further research to find effective treatments.2527 Autoimmunity Genetic evidence supports the autoimmune hypothesis as the main mechanism of vitiligo, with approximately 85% of susceptibility genes involved in innate, adaptive immunity, and apoptosis.4,28 This theory is also reinforced by the relationship of vitiligo with other autoimmune disorders, the presence of specific antibodies in patients, and the use of immunomodulatory therapies.4,28 Furthermore, it has been observed that treatments with immune checkpoint inhibitors in cancer patients can induce the development of vitiligo, suggesting a link between autoimmunity and this disease.29 Autoimmune diseases are the main comorbidity associated with vitiligo, including thyroid disorders, pernicious anemia, alopecia areata, connective tissue diseases, among others.30,31 Zombie cells, senescent cells in vitiligo Cellular senescence is induced in response to cellular stressors

Chang-rong Ge (Karolinska Institute, Stockholm, Sweden) for his generous assistance in manuscript preparation and amendment

7 FinelliC.SommellaL.GioiaS.La SalaN.TarantinoG

doi: 10.1016/j.bbrc.2018.12.039 25 RoennebergTMerrowM

These compounds include the pan-kinase inhibitor staurosporine, which induced stabilization by 4.8 C

doi: 10.1242/jcs.01357 214 LammerdingJSchulzePCTakahashiTKozlovSSullivanTKammRDet al