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In The X-Files , CSM has convinced himself that his manipulation and lies are necessary to maintain blissful human ignorance

Mazzone states

This is based on the assumption that tobacco smoking is overwhelmingly the most important cause of lung cancer, and that the incidence of this disease in the absence of smoking would be more or less the same in all populations, so that contemporary incidence (or mortality) rates from lung cancer simply reflect the cumulative exposure of a particular population to tobacco smoking