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Without enough, your entire body can suffer from symptoms

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In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )

Maintenance Dosing Guidelines After the initial treatment, patients need maintenance dosing to keep vitamin B12 levels up