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Transfection of Cyp2E1 [145] or induction of Cyp2E1 by dimethyl sulfoxide (DMSO) [139], can restore at least in part the metabolic capacity of HepG2 cells but the overall gene expression profile of HepG2 cells shows low similarity to primary human hepatocytes [146, 147]

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Data of another meta-analysis also indicate better semen quality in infertile men who received AOX supplementation after varicocelectomy (101)

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doi: 10.1038/s41419-023-05708-0 139 LiXYangQLiuSSongSWangC

This process of reduction is catalysed by bacteria present in the intestines (normal intestinal flora) which produce the enzyme [7]