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Epidemiological studies, as reported by Agency for Toxic Substances and Disease Registry (ATSDR) (5), indicate that over 5 million people are exposed to dangerous metals like Cd annually, known for their toxic properties and cumulative effects (18)

Among significantly upregulated genes (Dataset EV1) we found known factors upregulated by brain injury such as the JNK target mmp1 and several GO terms related to redox-dependent processes (Fig EV1A)

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