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Vavala E, Mignogna G, Spano F, Stringaro A, Colone M, et al

"It's that we don't have enough human data for most of the ones being marketed for anti-aging, athletic performance, etc

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Senescent-like microglia, in contrast, limit remyelination through SASP that involves the release of multiple inflammatory mediators, including CCL11, CXCL9, and CCL5, and increased expression of IL-2, leading to impaired remyelination in mouse models (Gross et al., 2025)

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While anecdotal reports cannot replace controlled research, they offer real-world perspectives on dosing, cycling, stacking, and subjective effects across diverse populations