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How it Works Nicotinamide provides essential nutrients for the use of cellular growth and maintenance, nicotinamide is also an attractive therapeutic agent

Standard care consisted of intravenous administration of 500 ml of physiologic saline solution (NaCl 9%) over a period of 15 min

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Mechanistically, cancer cells capable of inducing cancer cachexia are secreting IL-6, which subsequently induces autophagy in differentiated muscle cells via IL-6 signaling and therefore might be relevant for the characteristic muscle and weight loss during cancer cachexia (276)

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