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A loss of APP correlates with lower extracellular D-serine levels, higher total D-serine levels, and diminished dendritic spine dynamics

This is not surprising, since the main phenotypes of this syndrome (obesity, infertility and hirsutism) are major problems that can cause psychological stress

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A Review of N-Acetylcysteine in the Treatment of Grooming Disorders, 2019 Tara L Braun MD, Viraat Patel MD, Logan C DeBord BA, Theodore Rosen MD A trial of NAC may be a viable option for pathologic grooming disorders, especially in patients who have failed prior psychologic or pharmacologic treatment

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