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Targeting p53 in vivo : a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

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Suppression of H3K9me2/me3 demethylase activity such as KDM3A (JMJD1A), KDM4C (JMJD2C), and KDM7C (PHF2) in tissue specific stem cell cultures and cancer cells can lead to premature senescence, increased DNA damage and genomic instability (Huang et al., 2019

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Thus, the accelerated resistance previously observed (Figure 1) does not appear to be due to an altered genotype

10.1016/j.bioactmat.2022.11.019 145 NsairatH.KhaterD.SayedU.OdehF.Al BawabA.AlshaerW