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Specifically, the Na/K ATPase activity is impaired in several UV exposure models, which is likely to impair the specialised transport system known to maintain lens tissue transparency (265)

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#Pharmacovigilance #DrugSafety #PVQuality #PatientSafety #Compliance #LifeSciences To view or add a comment, sign in Day 7 | Pharmacovigilance Learning Journey Today I learned about Reporting Timelines in Pharmacovigilance

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Med Hypotheses 85(4):399404

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sUA and MSU crystals regulate monocyte MSU crystals induce monocyte-associated inflammation.MSU crystals directly instigate the assembly of NLRP3 inflammasome in monocytes, leading to an increase in IL-1 production ( via nuclear factor kappa-B(NF-B)/NLRP3/gasdermin D(GSDMD) signaling pathway activation

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Further investigation of the molecular mechanisms governing lactylation writers and erasers is essential for developing a comprehensive understanding of this PTM system and elucidating complex interactions among various PTMs

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